Article
p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.
Proceedings of the National Academy of Sciences of the United States of America - 12 Aug 2014
Senturk Serif, Yao Zhan, Camiolo Matthew, Stiles Brendon, Rathod Trushar, Walsh Alice M, Nemajerova Alice, Lazzara Matthew J, Altorki Nasser K, Krainer Adrian, Moll Ute M, Lowe Scott W, Cartegni Luca, Sordella Raffaella
Abstract excerpt
Although much is known about the underlying mechanisms of p53 activity and regulation, the factors that influence the diversity and duration of p53 responses are not well understood. Here we describe a unique mode of p53 regulation involving alternative splicing of the TP53 gene. We found that the use of an alternative 3' splice site in intron 6 generates a unique p53 isoform, dubbed p53Ψ. At the molecular level,...
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