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Article

p53's Extended Reach: The Mutant p53 Secretome.

Biomolecules - 15 Feb 2020

Pavlakis Evangelos, Stiewe Thorsten

Abstract excerpt

p53 suppresses tumorigenesis by activating a plethora of effector pathways. While most of these operate primarily inside of cells to limit proliferation and survival of incipient cancer cells, many extend to the extracellular space. In particular, p53 controls expression and secretion of numerous extracellular factors that are either soluble or contained within extracellular vesicles such as exosomes. As part of...

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Share to Carcinogenesis
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Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Microenvironment

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 32075247
DOI: 10.3390/biom10020307
PMCID: PMC7072272

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