Article
TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions.
eLife - 19 Oct 2016
Shirole Nitin H, Pal Debjani, Kastenhuber Edward R, Senturk Serif, Boroda Joseph, Pisterzi Paola, Miller Madison, Munoz Gustavo, Anderluh Marko, Ladanyi Marc, Lowe Scott W, Sordella Raffaella
Abstract excerpt
TP53 truncating mutations are common in human tumors and are thought to give rise to p53-null alleles. Here, we show that TP53 exon-6 truncating mutations occur at higher than expected frequencies and produce proteins that lack canonical p53 tumor suppressor activities but promote cancer cell proliferation, survival, and metastasis. Functionally and molecularly, these p53 mutants resemble the naturally occurring...
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