Article
Evaluation of gidB alterations responsible for streptomycin resistance in Mycobacterium tuberculosis.
The Journal of antimicrobial chemotherapy - 1 Nov 2014
Verma Jitender S, Gupta Yash, Nair Deepthi, Manzoor Nikhat, Rautela Rajinder S, Rai Arvind, Katoch Vishwa M
Abstract excerpt
OBJECTIVES: To evaluate gidB alterations for possible impact on the cumulative mechanism underlying the acquisition of high-level streptomycin resistance in Mycobacterium tuberculosis. METHODS: Fifty-two isolates with high streptomycin resistance and 23 isolates with low streptomycin resistance were sequenced for mutational analysis in the rpsL, rrs and gidB region. As the gidB protein has a complex substrate and...
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