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Article

High-throughput mutagenesis and screening approach for the identification of drug-resistant mutations in the rifampicin resistance-determining region of mycobacteria.

International journal of antimicrobial agents - 1 Jun 2024

Zhao Hui, Li Jiachen, Feng Siyuan, Xu Lin, Yan Bin, Li Chengjuan, Li Meisong, Wang Yaxuan, Li Yaxin, Liang Lujie, Zhou Dianrong, Wan Jia, Wang Wenli, Tian Guo-Bao, Gu Bing, Huang Xi

Abstract excerpt

Rifampicin is the most powerful first-line antibiotic for tuberculosis, which is caused by Mycobacterium tuberculosis. Although accumulating evidence from sequencing data of clinical M. tuberculosis isolates suggested that mutations in the rifampicin-resistance-determining region (RRDR) are strongly associated with rifampicin resistance, the comprehensive characterisation of RRDR polymorphisms that confer this...

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PMID: 38537722
DOI: 10.1016/j.ijantimicag.2024.107158

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