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Genetic Ablation of Metadherin Inhibits Autochthonous Prostate Cancer Progression and Metastasis

29 Jul 2014

Abstract excerpt

Metadherin (MTDH) overexpression in diverse cancer types has been linked to poor clinical outcomes, but definitive genetic proof of its contributions to cancer remains incomplete. In particular, the degree to which MTDH may contribute to malignant progression in vivo is lacking. Here, we report that MTDH is amplified frequently in human prostate cancers where its expression levels are tightly correlated with...

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PMID: 25074613
DOI: 10.1158/0008-5472.can-14-1349

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