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Article

Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer.

Molecular and cellular biology - 1 Sept 2010

Kinney Shannon R Morey, Moser Michael T, Pascual Marien, Greally John M, Foster Barbara A, Karpf Adam R

Abstract excerpt

Previous studies have shown that tumor progression in the transgenic adenocarcinoma of mouse prostate (TRAMP) model is characterized by global DNA hypomethylation initiated during early-stage disease and locus-specific DNA hypermethylation occurring predominantly in late-stage disease. Here, we utilized Dnmt1 hypomorphic alleles to examine the role of Dnmt1 in normal prostate development and in prostate cancer in...

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Identifiers

PMID: 20584988
DOI: 10.1128/MCB.00235-10
PMCID: PMC2937561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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