Article

CDH3 as a Novel Therapeutic Target in Basal-like Double-Negative Prostate Cancer

2025-11-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Basal-like (also known as double-negative) prostate cancers are aggressive tumors that lack effective targeted therapies. We aimed to delineate the role of CDH3 (P-cadherin) in basal-like prostate cancer and evaluate CDH3-directed therapeutic strategies. <h4>Methods</h4> We integrated genetically engineered mouse models (GEMMs) of prostate cancer, bulk and single-cell transcri...

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Literature Corpus work: e6d35cf0-999a-5ec3-b9d6-56322a18304c
DOI: 10.1101/2025.11.18.689150

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