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Metadherin: An emerging key regulator of the malignant progression of multiple cancers

7 Jul 2011

Abstract excerpt

We and others recently identified the gene metadherin (MTDH) as a functional driver in multiple aspects of cancer progression. It is overexpressed in cancer cells originating from a variety of tissues, partially due to DNA amplification of the chromosomal 8q22 region where this gene resides. The rapidly accumulated data from MTDH studies of the past several years have documented its role in tumorigenesis,...

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PMID: 27755853
DOI: 10.1111/j.1759-7714.2011.00064.x

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Metadherin: An emerging key regulator of the malignant progression of multiple cancersPMID 27755853Read ↗

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Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem–like Cell Traits in Breast CancerSemantic proximity Read ↗

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Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug ResistanceSemantic proximity Read ↗

MicroRNA-320a inhibits breast cancer metastasis by targeting metadherinSemantic proximity Read ↗

MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cellsSemantic proximity Read ↗

Genetic Ablation of Metadherin Inhibits Autochthonous Prostate Cancer Progression and MetastasisSemantic proximity Read ↗

MTDH Promotes Cancer Stem Cell Phenotypes and Correlated with Immune Infiltration in Hepatocellular CarcinomaSemantic proximity Read ↗

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Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma.Semantic proximity Read ↗

The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A ReviewSemantic proximity Read ↗

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