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Inhibition of KDM4C/c‐Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism

1 Mar 2022

Abstract excerpt

Dear Editor, we discovered that knockout of KDM4C can effectively suppress prostate cancer (PCa) cells’ migration and invasion. We identified that targeting KDM4C/c-Myc/LDHA signalling can be an effective prevention for metastatic PCa. Epigenetics change is an important feature in cancer metabolism reprograming and metabolism rewiring can enhance cancer progression. Histone lysine demethylase 4C (KDM4C), which...

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PMID: 35343073
DOI: 10.1002/ctm2.764

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