Article

HVEM is a Novel Immune Checkpoint for Prostate Cancer Immunotherapy in Humanized Mice

2021-06-09

Abstract excerpt

The Herpes Virus Entry Mediator (HVEM) delivers a negative signal to T cells mainly through the B and T Lymphocyte Attenuator (BTLA) molecule and thus, could represent a novel immune checkpoint during an anti-tumor immune response. A formal demonstration that HVEM can be targeted for cancer immunotherapy is however still lacking. Here, we first show that HVEM and BTLA were associated to a worse prognosis in patien...

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Literature Corpus work: d32f7cd2-f089-5535-87b6-b6ea70a8d417
DOI: 10.20944/preprints202105.0302.v2

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