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Article

CDKN2A(p16) and HRAS are frequently mutated in vulvar squamous cell carcinoma.

Gynecologic oncology - 1 Oct 2014

Trietsch Marjolijn D, Spaans Vivian M, ter Haar Natalja T, Osse Elisabeth M, Peters Alexander A W, Gaarenstroom Katja N, Fleuren Gert Jan

Abstract excerpt

BACKGROUND: Two etiologic pathways of vulvar cancer are known, a human papillomavirus (HPV)- and a TP53-associated route, respectively, but other genetic changes may also play a role. Studies on somatic mutations in vulvar cancer other than TP53 are limited in number and size. In this study, we investigated the prevalence of genetic mutations in 107 vulvar squamous cell carcinomas (VSCCs). METHODS: A total of 107...

Topics

Aged
Carcinoma, Squamous Cell
Cyclin-Dependent Kinase Inhibitor p16
Female
Genes, p16
Humans
Mutation
Neoplasm Proteins
Proto-Oncogene Proteins p21(ras)
Survival Rate
Vulvar Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25072932
DOI: 10.1016/j.ygyno.2014.07.094

Genes

HRAS
KRAS
PTEN
BRAF
CTNNB1
FGFR2
FGFR3
FOXL2
NRAS

Provenance

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