p53 and p16 expression profiles in vulvar cancer: a translational analysis by the Arbeitsgemeinschaft Gynäkologische Onkologie Chemo and Radiotherapy in Epithelial Vulvar Cancer study group.

doi:10.1016/j.ajog.2020.12.1220

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Article

p53 and p16 expression profiles in vulvar cancer: a translational analysis by the Arbeitsgemeinschaft Gynäkologische Onkologie Chemo and Radiotherapy in Epithelial Vulvar Cancer study group.

American journal of obstetrics and gynecology - 1 Jun 2021

Woelber Linn, Prieske Katharina, Eulenburg Christine, Oliveira-Ferrer Leticia, de Gregorio Nikolaus, Klapdor Ruediger, Kalder Matthias, Braicu Iona, Fuerst Sophie, Klar Maximilian, Strauss Hans-Georg, Beckmann Matthias, Meier Werner, Ignatov Atanas, Mustea Alexander, Jueckstock Julia, Schmidt Georg, Bauerschlag Dirk, Hellriegel Martin, Canzler Ulrich, Petry Karl Ulrich, Kommoss Stefan, Hantschmann Peer, Heubner Martin, Mahner Sven, Burandt Eike

Abstract excerpt

BACKGROUND: There are 2 known pathways for tumorigenesis of vulvar squamous cell carcinoma-a human papillomavirus-dependent pathway characterized by p16 overexpression and a human papillomavirus-independent pathway linked to lichen sclerosus, characterized by TP53 mutation. A correlation of human papillomavirus dependency with a favorable prognosis has been proposed. OBJECTIVE: The objective of the study was to...

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PMID: 33453182
DOI: 10.1016/j.ajog.2020.12.1220

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