A review of reviews of the prevalence of molecular biomarkers in vulvar cancer and their implications for prognosis refinement and treatment strategies.

doi:10.1016/j.ygyno.2026.05.015

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Article

A review of reviews of the prevalence of molecular biomarkers in vulvar cancer and their implications for prognosis refinement and treatment strategies.

Gynecologic oncology - 1 Jul 2026

Trozzi Rita, Anderson Gloria, Romano Viviana, Iacobelli Valentina, Giovannetti Agnese, Sabetta Giulia, Dababou Susan, Ganev Alexandra, Mazza Tommaso, Adinolfi Marta, Duranti Simona, Camarda Floriana, Fragomeni Simona Maria, Federico Alex, Ferrandina Gabriella Maria, Roma Cristin, Scollo Paolo, Marth Christian, Zannoni Gian Franco, Fagotti Anna, Garganese Giorgia, Nero Camilla

Abstract excerpt

BACKGROUND: To clarify the prevalence and clinical utility of molecular biomarkers in vulvar cancer, we performed a review of systematic and high-quality narrative reviews, complemented by interrogation of public repositories containing genomic datasets. Our objectives were to (i) quantify biomarker prevalence across vulvar cancer subtypes, (ii) evaluate their prognostic and predictive value, and (iii) identify...

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PMID: 42155564
DOI: 10.1016/j.ygyno.2026.05.015

Genes

BRAF
CDKN2A
ERBB2
FGFR3
HRAS
KIT
PIK3CA
TP53

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