Article
Genomic Characterization of Vulvar (Pre)cancers Identifies Distinct Molecular Subtypes with Prognostic Significance.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2017
Nooij Linda S, Ter Haar Natalja T, Ruano Dina, Rakislova Natalia, van Wezel Tom, Smit Vincent T H B M, Trimbos Baptist J B M Z, Ordi Jaume, van Poelgeest Mariette I E, Bosse Tjalling
Abstract excerpt
Purpose: Vulvar cancer (VC) can be subclassified by human papillomavirus (HPV) status. HPV-negative VCs frequently harbor TP53 mutations; however, in-depth analysis of other potential molecular genetic alterations is lacking. We comprehensively assessed somatic mutations in a large series of vulvar (pre)cancers.Experimental Design: We performed targeted next-generation sequencing (17 genes), p53...
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