Mutations Elevate an Underground Pathway to a Physiologically Relevant Protopathway.

Abstract excerpt

Underground metabolic pathways-leaks in the metabolic network caused by promiscuous enzyme activities and nonenzymatic transformations-can provide the starting point for emergence of novel protopathways if a mutation or environmental change increases flux to a physiologically significant level. This early stage in pathway evolution, in which promiscuous enzymes are still serving their native functions and proper...

Topics

• Escherichia coli
• Mutation
• Metabolic Networks and Pathways
• Pyridoxal Phosphate
• Escherichia coli Proteins