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Article

Basic and applied uses of genome-scale metabolic network reconstructions of Escherichia coli.

Molecular systems biology - 1 Jan 2013

McCloskey Douglas, Palsson Bernhard Ø, Feist Adam M

Abstract excerpt

The genome-scale model (GEM) of metabolism in the bacterium Escherichia coli K-12 has been in development for over a decade and is now in wide use. GEM-enabled studies of E. coli have been primarily focused on six applications: (1) metabolic engineering, (2) model-driven discovery, (3) prediction of cellular phenotypes, (4) analysis of biological network properties, (5) studies of evolutionary processes, and (6)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23632383
DOI: 10.1038/msb.2013.18
PMCID: PMC3658273

Genes

GEM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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