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Article

Annotating the pangenome reveals the diversity in the genetic basis for metabolic enzymes.

Science advances - 3 Jul 2026

Ardalani Omid, Phaneuf Patrick V, Krishnan Kalpathy J, Pride David, Nielsen Lars K, Palsson Bernhard O

Abstract excerpt

Affordable sequencing has flooded public databases with bacterial genomes; yet, species-scale maps that connect gene content variation to metabolic functions essential to biotechnology/system biology remain scarce. We address this gap by building a pangenome-wide gene-protein-reaction association and applying it to 2377 Escherichia coli genomes to reconstruct a pangenome-scale metabolic model (panGEM). We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42384800
DOI: 10.1126/sciadv.aeb3363
PMCID: PMC13322260

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