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Article

Superessential reactions in metabolic networks.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 2012

Barve Aditya, Rodrigues João Frederico Matias, Wagner Andreas

Abstract excerpt

The metabolic genotype of an organism can change through loss and acquisition of enzyme-coding genes, while preserving its ability to survive and synthesize biomass in specific environments. This evolutionary plasticity allows pathogens to evolve resistance to antimetabolic drugs by acquiring new metabolic pathways that bypass an enzyme blocked by a drug. We here study quantitatively the extent to which...

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Identifiers

PMID: 22509034
DOI: 10.1073/pnas.1113065109
PMCID: PMC3345022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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