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Article

Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism.

Molecular systems biology - 1 Jan 2009

Nakahigashi Kenji, Toya Yoshihiro, Ishii Nobuyoshi, Soga Tomoyoshi, Hasegawa Miki, Watanabe Hisami, Takai Yuki, Honma Masayuki, Mori Hirotada, Tomita Masaru

Abstract excerpt

Central carbon metabolism is a basic and exhaustively analyzed pathway. However, the intrinsic robustness of the pathway might still conceal uncharacterized reactions. To test this hypothesis, we constructed systematic multiple-knockout mutants involved in central carbon catabolism in Escherichia coli and tested their growth under 12 different nutrient conditions. Differences between in silico predictions and...

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Identifiers

PMID: 19756045
DOI: 10.1038/msb.2009.65
PMCID: PMC2758719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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