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Functional and physical interaction between the mismatch repair and FA-BRCA pathways

24 Aug 2011

Abstract excerpt

Fanconi anemia (FA) is a rare genetic disorder characterized by bone marrow failure and an increased risk for leukemia and cancer. Fifteen proteins thought to function in the repair of DNA interstrand crosslinks (ICLs) comprise what is known as the FA-BRCA pathway. Activation of this pathway leads to the monoubiquitylation and chromatin localization of FANCD2 and FANCI. It has previously been shown that FANCJ...

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PMID: 21865299
DOI: 10.1093/hmg/ddr366

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