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Article

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

Cell - 20 Apr 2007

Smogorzewska Agata, Matsuoka Shuhei, Vinciguerra Patrizia, McDonald E Robert, Hurov Kristen E, Luo Ji, Ballif Bryan A, Gygi Steven P, Hofmann Kay, D'Andrea Alan D, Elledge Stephen J

Abstract excerpt

Fanconi anemia (FA) is a developmental and cancer-predisposition syndrome caused by mutations in genes controlling DNA interstrand crosslink repair. Several FA proteins form a ubiquitin ligase that controls monoubiquitination of the FANCD2 protein in an ATR-dependent manner. Here we describe the FA protein FANCI, identified as an ATM/ATR kinase substrate required for resistance to mitomycin C. FANCI shares...

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Source

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Identifiers

PMID: 17412408
DOI: 10.1016/j.cell.2007.03.009
PMCID: PMC2175179

Genes

FANCI
FANCD2
ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.PMID 17412408Read ↗

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.Semantic proximity Read ↗

Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.Semantic proximity Read ↗

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.Semantic proximity Read ↗

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.Semantic proximity Read ↗

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.Semantic proximity Read ↗

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.Semantic proximity Read ↗

Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair PathwaySemantic proximity Read ↗

Structural insight into FANCI-FANCD2 monoubiquitination.Semantic proximity Read ↗

Role of Fanconi anaemia proteins FANCG, FANCA and FANCD2 in the maintenance of chromosomal stabilitySemantic proximity Read ↗

Fanconi anemia and DNA repair.Semantic proximity Read ↗

Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing.Semantic proximity Read ↗

The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair PathwaySemantic proximity Read ↗

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