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Article

Global genetic architecture of an erythroid quantitative trait locus, HMIP-2.

Annals of human genetics - 1 Nov 2014

Menzel Stephan, Rooks Helen, Zelenika Diana, Mtatiro Siana N, Gnanakulasekaran Akshala, Drasar Emma, Cox Sharon, Liu Li, Masood Mariam, Silver Nicholas, Garner Chad, Vasavda Nisha, Howard Jo, Makani Julie, Adekile Adekunle, Pace Betty, Spector Tim, Farrall Martin, Lathrop Mark, Thein Swee Lay

Abstract excerpt

HMIP-2 is a human quantitative trait locus affecting peripheral numbers, size and hemoglobin composition of red blood cells, with a marked effect on the persistence of the fetal form of hemoglobin, HbF, in adults. The locus consists of multiple common variants in an enhancer region for MYB (chr 6q23.3), which encodes the hematopoietic transcription factor cMYB. Studying a European population cohort and four...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25069958
DOI: 10.1111/ahg.12077
PMCID: PMC4303951

Genes

MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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