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Article

The association of HBG2, BCL11A, and HMIP polymorphisms with fetal hemoglobin and clinical phenotype in Iraqi Kurds with sickle cell disease.

International journal of laboratory hematology - 1 Feb 2019

Al-Allawi Nasir, Qadir Shatha M A, Puehringer Helene, Chui David H K, Farrell John J, Oberkanins Christian

Abstract excerpt

INTRODUCTION: Fetal hemoglobin (HbF) is the major modifier for sickle cell disease (SCD) severity. HbF is modulated mainly by three major quantitative trait loci (QTL) on chromosomes 2, 6, and 11. METHODS: Five SNPs in the three QTLs (HBG2, rs7482144; BCL11A, rs1427407 and rs10189857; and HBS1L-MYB intergenic region, rs28384513 and rs9399137) were investigated by multiplex PCR and reverse hybridization, and their...

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PMID: 30216683
DOI: 10.1111/ijlh.12927

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