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Article

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.

Human molecular genetics - 15 Oct 2009

Thein Swee Lay, Menzel Stephan, Lathrop Mark, Garner Chad

Abstract excerpt

Increased levels of fetal hemoglobin (HbF, alpha(2)gamma(2)) are of no consequence in healthy adults, but confer major clinical benefits in patients with sickle cell anemia (SCA) and beta thalassemia, diseases that represent major public health problems. Inter-individual HbF variation is largely genetically controlled, with one extreme caused by mutations involving the beta globin gene (HBB) complex, historically...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19808799
DOI: 10.1093/hmg/ddp401
PMCID: PMC2758709

Genes

HBB
HBG2
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.PMID 19808799Read ↗

Genetic architecture of hemoglobin F controlSemantic proximity Read ↗

Discovering the genetics underlying foetal haemoglobin production in adultsSemantic proximity Read ↗

Regulation of human fetal hemoglobin: new players, new complexitiesSemantic proximity Read ↗

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.Semantic proximity Read ↗

Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease.Semantic proximity Read ↗

Genetic association studies in β-hemoglobinopathiesSemantic proximity Read ↗

Fetal Hemoglobin Modulation in Sickle Cell Disease: βs Haplotypes, Key Polymorphisms Identified by GWAS, and Advances in γ-Globin Editing: An Updated Overview.Semantic proximity Read ↗

[Progress on genes related to fetal hemoglobin quantitative trait].Semantic proximity Read ↗

Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF) Levels and F-Cell Numbers: A Systematic Review of Genome-Wide Association Studies.Semantic proximity Read ↗

Single Nucleotide Polymorphisms in XMN1-HBG2, HBS1L-MYB, and BCL11A and Their Relation to High Fetal Hemoglobin Levels That Alleviate AnemiaSemantic proximity Read ↗

Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease.Semantic proximity Read ↗

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.Semantic proximity Read ↗

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