Article
Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.
American journal of human genetics - 5 Jan 2017
van Rooij Frank J A, Qayyum Rehan, Smith Albert V, Zhou Yi, Trompet Stella, Tanaka Toshiko, Keller Margaux F, Chang Li-Ching, Schmidt Helena, Yang Min-Lee, Chen Ming-Huei, Hayes James, Johnson Andrew D, Yanek Lisa R, Mueller Christian, Lange Leslie, Floyd James S, Ghanbari Mohsen, Zonderman Alan B, Jukema J Wouter, Hofman Albert, van Duijn Cornelia M, Desch Karl C, Saba Yasaman, Ozel Ayse B, Snively Beverly M, Wu Jer-Yuarn, Schmidt Reinhold, Fornage Myriam, Klein Robert J, Fox Caroline S, Matsuda Koichi, Kamatani Naoyuki, Wild Philipp S, Stott David J, Ford Ian, Slagboom P Eline, Yang Jaden, Chu Audrey Y, Lambert Amy J, Uitterlinden André G, Franco Oscar H, Hofer Edith, Ginsburg David, Hu Bella, Keating Brendan, Schick Ursula M, Brody Jennifer A, Li Jun Z, Chen Zhao, Zeller Tanja, Guralnik Jack M, Chasman Daniel I, Peters Luanne L, Kubo Michiaki, Becker Diane M, Li Jin, Eiriksdottir Gudny, Rotter Jerome I, Levy Daniel, Grossmann Vera, Patel Kushang V, Chen Chien-Hsiun, Ridker Paul M, Tang Hua, Launer Lenore J, Rice Kenneth M, Li-Gao Ruifang, Ferrucci Luigi, Evans Michelle K, Choudhuri Avik, Trompouki Eirini, Abraham Brian J, Yang Song, Takahashi Atsushi, Kamatani Yoichiro, Kooperberg Charles, Harris Tamara B, Jee Sun Ha, Coresh Josef, Tsai Fuu-Jen, Longo Dan L, Chen Yuan-Tsong, Felix Janine F, Yang Qiong, Psaty Bruce M, Boerwinkle Eric, Becker Lewis C, Mook-Kanamori Dennis O, Wilson James G, Gudnason Vilmundur, O'Donnell Christopher J, Dehghan Abbas, Cupples L Adrienne, Nalls Michael A, Morris Andrew P, Okada Yukinori, Reiner Alexander P, Zon Leonard I, Ganesh Santhi K
Abstract excerpt
Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We...