Article
Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction.
Molecular and cellular neurosciences - 1 Jul 2014
Blunk Aline D, Akbergenova Yulia, Cho Richard W, Lee Jihye, Walldorf Uwe, Xu Ke, Zhong Guisheng, Zhuang Xiaowei, Littleton J Troy
Abstract excerpt
Synaptic communication requires precise alignment of presynaptic active zones with postsynaptic receptors to enable rapid and efficient neurotransmitter release. How transsynaptic signaling between connected partners organizes this synaptic apparatus is poorly understood. To further define the mechanisms that mediate synapse assembly, we carried out a chemical mutagenesis screen in Drosophila to identify mutants...
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