Article
Drosophila ankyrin 2 is required for synaptic stability.
Neuron - 24 Apr 2008
Koch Iris, Schwarz Heinz, Beuchle Dirk, Goellner Bernd, Langegger Maria, Aberle Hermann
Abstract excerpt
Synaptic connections are stabilized through transsynaptic adhesion complexes that are anchored in the underlying cytoskeleton. The Drosophila neuromuscular junction (NMJs) serves as a model system to unravel genes required for the structural remodeling of synapses. In a mutagenesis screen for regulators of synaptic stability, we recovered mutations in Drosophila ankyrin 2 (ank2) affecting two giant Ank2 isoforms...
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