Article
Dynactin is necessary for synapse stabilization.
Neuron - 30 May 2002
Eaton Benjamin A, Fetter Richard D, Davis Graeme W
Abstract excerpt
We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex. Arp-1 dsRNA enhances synapse retraction, and this effect is phenocopied by a mutation in P150/Glued, also a dynactin component. The...
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