Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Malonyl coenzyme A decarboxylase deficiency: early dietary restriction and time course of cardiomyopathy.

Pediatrics - 1 Aug 2012

Prada Carlos E, Jefferies John L, Grenier Michelle A, Huth Christina M, Page Kimberley I, Spicer Robert L, Towbin Jeffrey A, Leslie Nancy D

Abstract excerpt

Malonyl coenzyme A (CoA) decarboxylase (MCD) deficiency is a rare autosomal recessive organic acidemia characterized by varying degrees of organ involvement and severity. MCD regulates fatty acid biosynthesis and converts malonyl-CoA to acetyl-CoA. Cardiomyopathy is 1 of the leading causes of morbidity and mortality in this disorder. It is unknown if diet alone prevents cardiomyopathy development based in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carboxy-Lyases
Share to Carnitine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Codon, Terminator

Share to Dietary Fats

Share to Isolated Noncompaction of the Ventricular Myocardium

Share to Metabolism, Inborn Errors

Share to Methylmalonic Acid

Share to Rare Diseases

Source

Identifiers

PMID: 22778304
DOI: 10.1542/peds.2011-2927

Genes

MLYCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Malonyl coenzyme A decarboxylase deficiency: early dietary restriction and time course of cardiomyopathy.PMID 22778304Read ↗

Use of a long-chain triglyceride-restricted/medium-chain triglyceride-supplemented diet in a case of malonyl-CoA decarboxylase deficiency with cardiomyopathy.Semantic proximity Read ↗

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.Semantic proximity Read ↗

A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy.Semantic proximity Read ↗

The clinical manifestation of MCAD deficiency: challenges towards adulthood in the screened population.Semantic proximity Read ↗

Clinical, biochemical and genetic characteristics and long-term follow-up of five patients with malonyl-CoA decarboxylase deficiency.Semantic proximity Read ↗

A new case of malonic aciduria with a presymptomatic diagnosis and an early treatment.Semantic proximity Read ↗

Malonyl coenzyme A decarboxylase deficiency with a novel mutation.Semantic proximity Read ↗

Cardiac phenotype in adolescents and young adults with long-chain 3-hydroxyacyl CoA dehydrogenase (LCHAD) deficiency.Semantic proximity Read ↗

Tachycardiomyopathy-like presentation in neonatal MCAD deficiency: A novel cardiac phenotype.Semantic proximity Read ↗

Late-onset multiple acyl-CoA dehydrogenase deficiency: an insidious presentation.Semantic proximity Read ↗

Clinical, enzymatic and molecular characterization of nine new patients with malonyl-coenzyme A decarboxylase deficiency.Semantic proximity Read ↗

MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.