Article
Spatially confined electrochemical strategy with DNA-assembled nanogaps for SNP detection.
Biosensors & bioelectronics - 1 Dec 2026
Chen Yuhan, Guo Rui, Zhu Liping, Wang Meng, Du Yeyao, Deng Weiping, Yang Ximiao, Zhang Yunshan, Feng Xianzhong, Zhang Diming, Ye Jing
Abstract excerpt
Accurate detection of low-abundance single nucleotide polymorphisms (SNPs) against a large excess of homologous wild-type sequences requires both selective molecular recognition and effective transduction of small sequence differences into measurable signals. Here, we report a spatially confined electrochemical strategy that couples sequence-selective recognition with size-dependent mass-transport gating....
Read the complete abstract on PubMedTopics
- Polymorphism, Single Nucleotide
- Biosensing Techniques
- Gold
- Metal Nanoparticles
- Electrochemical Techniques
- DNA