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Article

Comparison of the mammalian insulin signalling pathway to invertebrates in the context of FOXO-mediated ageing.

Bioinformatics (Oxford, England) - 1 Nov 2014

Papatheodorou Irene, Petrovs Rudolfs, Thornton Janet M

Abstract excerpt

MOTIVATION: A large number of experimental studies on ageing focus on the effects of genetic perturbations of the insulin/insulin-like growth factor signalling pathway (IIS) on lifespan. Short-lived invertebrate laboratory model organisms are extensively used to quickly identify ageing-related genes and pathways. It is important to extrapolate this knowledge to longer lived mammalian organisms, such as mouse and...

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Identifiers

PMID: 25064569
DOI: 10.1093/bioinformatics/btu493
PMCID: PMC4201157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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