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Article

Pleiotropic effects of growth hormone signaling in aging.

Trends in endocrinology and metabolism: TEM - 1 Nov 2011

Bartke Andrzej

Abstract excerpt

Growth hormone (GH) affects somatic growth, sexual maturation, body composition and metabolism, as well as aging and longevity. Mice lacking GH or GH receptor outlive their normal siblings and exhibit symptoms of delayed aging associated with improved insulin signaling and increased stress resistance. Beneficial effects of eliminating the actions of GH are counterintuitive but conform to the concept of...

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Identifiers

PMID: 21852148
DOI: 10.1016/j.tem.2011.07.004
PMCID: PMC4337825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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