Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations.

Adipocyte - 3 Apr 2017

Darcy Justin, McFadden Samuel, Bartke Andrzej

Abstract excerpt

A major focus of biogerontology is elucidating the role(s) of the endocrine system in aging and the accumulation of age-related diseases. Endocrine control of mammalian longevity was first reported in Ames dwarf (Prop1df) mice, which are long-lived due to a recessive Prop1 loss-of-function mutation resulting in deficiency of growth hormone (GH), thyroid-stimulating hormone, and prolactin. Following this report,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue, Brown
Share to Adipose Tissue, White
Share to Body Composition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Growth Hormone

Share to Insulin-Like Growth Factor I

Share to Prolactin

Share to Receptors, Somatotropin

Share to Thermogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 28425851
DOI: 10.1080/21623945.2017.1308990
PMCID: PMC5477739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations.PMID 28425851Read ↗

Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice.Semantic proximity Read ↗

GH and IGF1: roles in energy metabolism of long-living GH mutant mice.Semantic proximity Read ↗

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.Semantic proximity Read ↗

Life extension in the dwarf mouse.Semantic proximity Read ↗

Impact of Growth Hormone-Related Mutations on Mammalian AgingSemantic proximity Read ↗

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone productionSemantic proximity Read ↗

Prolonged longevity of hypopituitary dwarf mice.Semantic proximity Read ↗

Two-year body composition analyses of long-lived GHR null mice.Semantic proximity Read ↗

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice.Semantic proximity Read ↗

Longevity is impacted by growth hormone action during early postnatal period.Semantic proximity Read ↗

Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice.Semantic proximity Read ↗

The Effects of Growth Hormone (GH) Treatment on GH and Insulin/IGF-1 Signaling in Long-Lived Ames Dwarf MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.