Article
CRISPR-Cas: an efficient tool for genome engineering of virulent bacteriophages.
Nucleic acids research - 1 Aug 2014
Martel Bruno, Moineau Sylvain
Abstract excerpt
Bacteriophages are now widely recognized as major players in a wide variety of ecosystems. Novel genes are often identified in newly isolated phages as well as in environmental metavirome studies. Most of these novel viral genes have unknown functions but appear to be coding for small, non-structural proteins. To understand their biological role, very efficient genetic tools are required to modify them,...
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