Article
The action of Escherichia coli CRISPR-Cas system on lytic bacteriophages with different lifestyles and development strategies.
Nucleic acids research - 28 Feb 2017
Strotskaya Alexandra, Savitskaya Ekaterina, Metlitskaya Anastasia, Morozova Natalia, Datsenko Kirill A, Semenova Ekaterina, Severinov Konstantin
Abstract excerpt
CRISPR-Cas systems provide prokaryotes with adaptive defense against bacteriophage infections. Given an enormous variety of strategies used by phages to overcome their hosts, one can expect that the efficiency of protective action of CRISPR-Cas systems against different viruses should vary. Here, we created a collection of Escherichia coli strains with type I-E CRISPR-Cas system targeting various positions in the...
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