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Article

Unexpected evolutionary benefit to phages imparted by bacterial CRISPR-Cas9.

Science advances - 1 Feb 2018

Tao Pan, Wu Xiaorong, Rao Venigalla

Abstract excerpt

Bacteria and bacteriophages arm themselves with various defensive and counterdefensive mechanisms to protect their own genome and degrade the other's. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas (CRISPR-associated) is an adaptive bacterial defense mechanism that recognizes short stretches of invading phage genome and destroys it by nuclease attack. Unexpectedly, we discovered that the...

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Identifiers

PMID: 29457136
DOI: 10.1126/sciadv.aar4134
PMCID: PMC5812732

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