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Article

An anti-CRISPR from a virulent streptococcal phage inhibits Streptococcus pyogenes Cas9.

Nature microbiology - 1 Oct 2017

Hynes Alexander P, Rousseau Geneviève M, Lemay Marie-Laurence, Horvath Philippe, Romero Dennis A, Fremaux Christophe, Moineau Sylvain

Abstract excerpt

The CRISPR-Cas system owes its utility as a genome-editing tool to its origin as a prokaryotic immune system. The first demonstration of its activity against bacterial viruses (phages) is also the first record of phages evading that immunity 1 . This evasion can be due to point mutations 1 , large-scale deletions 2 , DNA modifications 3 , or phage-encoded proteins that interfere with the CRISPR-Cas system, known...

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PMID: 28785032
DOI: 10.1038/s41564-017-0004-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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