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Article

Genomic impact of CRISPR immunization against bacteriophages.

Biochemical Society transactions - 1 Dec 2013

Barrangou Rodolphe, Coûté-Monvoisin Anne-Claire, Stahl Buffy, Chavichvily Isabelle, Damange Florian, Romero Dennis A, Boyaval Patrick, Fremaux Christophe, Horvath Philippe

Abstract excerpt

CRISPR (clustered regularly interspaced short palindromic repeats) together with CAS (RISPR-associated) genes form the CRISPR-Cas immune system, which provides sequence-specific adaptive immunity against foreign genetic elements in bacteria and archaea. Immunity is acquired by the integration of short stretches of invasive DNA as novel 'spacers' into CRISPR loci. Subsequently, these immune markers are transcribed...

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Identifiers

PMID: 24256225
DOI: 10.1042/BST20130160

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