Article
Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice.
Journal of neuroinflammation - 25 Jul 2014
Weekman Erica M, Sudduth Tiffany L, Abner Erin L, Popa Gabriel J, Mendenhall Michael D, Brothers Holly M, Braun Kaitlyn, Greenstein Abigail, Wilcock Donna M
Abstract excerpt
BACKGROUND: The polarization to different neuroinflammatory phenotypes has been described in early Alzheimer's disease, yet the impact of these phenotypes on amyloid-beta (Aβ) pathology remains unknown. Short-term studies show that induction of an M1 neuroinflammatory phenotype reduces Aβ, but long-term studies have not been performed that track the neuroinflammatory phenotype. METHODS: Wild-type and APP/PS1...
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