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Article

M2-Like Microglia Polarization Attenuates Neuropathic Pain Associated with Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Jin Jing, Guo Jia, Cai Hongbin, Zhao Chongchong, Wang Huan, Liu Zhiyan, Ge Zhao-Ming

Abstract excerpt

Many Alzheimer's disease (AD) patients suffer from persistent neuropathic pain (NP), which is mediated, at least partially, but microglia. Nevertheless, the exact underlying mechanism is unknown. Moreover, a clinically translatable approach through modulating microglia for treating AD-associated NP is not available. Here, in a doxycycline-induced mouse model (rTg4510) for AD, we showed development of NP. We found...

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Identifiers

PMID: 32280102
DOI: 10.3233/JAD-200099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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