Article
[Fasudil improves cognition of APP/PS1 transgenic mice via inhibiting the activation of microglia and shifting microglia phenotypes from M1 to M2].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology - 1 Dec 2017
Yu Jiezhong, Gu Qingfang, Yan Yuqing, Yu Hongqiang, Guo Minfang, Liu Chunyun, Song Guobin, Chai Zhi, Wang Qing, Xiao Baoguo, Zhang Hanting, Jiang Yuqiang, Ma Cungen
Abstract excerpt
Objective To examine the regulatory effects of Rho kinase inhibitor fasudil on cognition and microglia polarization in APP/PS1 transgenic (APP/PS1 Tg) mice, a widely used model of Alzheimer's disease (AD). Methods Male APP/PS1 Tg mice at 8 months of age were randomly divided into two groups: Fasudil (25 mg/kg) and saline, i.p., once daily for 2 months; age- and gender-matched wild type (WT) mice without treatment...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.