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Article

Testing gene-environment interactions for rare and/or common variants in sequencing association studies.

PloS one - 1 Jan 2020

Zhao Zihan, Zhang Jianjun, Sha Qiuying, Hao Han

Abstract excerpt

The risk of many complex diseases is determined by a complex interplay of genetic and environmental factors. Advanced next generation sequencing technology makes identification of gene-environment (GE) interactions for both common and rare variants possible. However, most existing methods focus on testing the main effects of common and/or rare genetic variants. There are limited methods developed to test the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32155162
DOI: 10.1371/journal.pone.0229217
PMCID: PMC7064198

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