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Article

Does accounting for gene-environment interactions help uncover association between rare variants and complex diseases?

Human heredity - 1 Jan 2012

Kazma Rémi, Cardin Niall J, Witte John S

Abstract excerpt

OBJECTIVE: To determine whether accounting for gene-environment (G×E) interactions improves the power to detect associations between rare variants and a disease, we have extended three statistical methods and compared their power under various simulated disease models. METHODS: To test for association of a group of rare variants with a disease, Min-P uses the lowest p value within the group of variants, CAST...

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PMID: 23594498
DOI: 10.1159/000346825

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CAST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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