Article
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.
The American journal of pathology - 1 Sept 2004
Sadowski Marcin, Pankiewicz Joanna, Scholtzova Henrieta, Ripellino James A, Li Yongsheng, Schmidt Stephen D, Mathews Paul M, Fryer John D, Holtzman David M, Sigurdsson Einar M, Wisniewski Thomas
Abstract excerpt
Alzheimer's disease (AD) is associated with accumulation of beta-amyloid (Abeta). A major genetic risk factor for sporadic AD is inheritance of the apolipoprotein (apo) E4 allele. ApoE can act as a pathological chaperone of Abeta, promoting its conformational transformation from soluble Abeta into toxic aggregates. We determined if blocking the apoE/Abeta interaction reduces Abeta load in transgenic (Tg) AD mice....
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