Article
Two single nucleotide polymorphisms in TSLP gene are associated with asthma susceptibility in Chinese Han population.
Experimental lung research - 1 Oct 2012
Liu Wen, Xu Li-Sheng, Liu Qi-Ji, Dong Fang-Zheng, Qiu Rong-Fang, Wen Ming-Chun, Han Yu-Ling, Tang Ning-Bo, Kang Li-Jun, Wu Jin-Xiang, Liu Fen, Zhao Ji-Ping, Yang Meng-Meng, Wang Jun-Fei, Ding Ming-Jie, Sun Yue-Mei, Fei Wen-Jian, Dong Liang
Abstract excerpt
BACKGROUND: Asthma is a chronic inflammatory disease of the airway that is mediated by T-helper 2(TH2) cells. Thymic stromal lymphopoietin (TSLP) can aggravate asthmatic lung inflammation by activating dendritic cells (DCs) to promote TH2 differentiation. TSLP promoter polymorphisms are associate...
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