Article

FOXA2 is essential for maintaining the urea cycle in acute liver failure

2023-12-11

Abstract excerpt

Hepatic encephalopathy is a lethal complication of acute liver failure (ALF), and is caused by hyperammonemia. Ammonia clearance by the liver requires an intact and complete urea cycle comprising six enzymes, including the rate-limiting enzyme carbamoyl phosphate synthetase I (CPS1). To date, the detailed regulation of CPS1 transcription in order to maintain urea cycle in physiological condition and ALF remains la...

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Literature Corpus work: 3f8ed247-e49f-5834-9e89-464b6244855b
DOI: 10.1101/2023.12.11.570955

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