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Article

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

Nature communications - 14 Jul 2016

Kim Dong-Hyun, Kwon Sanghoon, Byun Sangwon, Xiao Zhen, Park Sean, Wu Shwu-Yuan, Chiang Cheng-Ming, Kemper Byron, Kemper Jongsook Kim

Abstract excerpt

Bile acids (BAs) are recently recognized signalling molecules that profoundly affect metabolism. Because of detergent-like toxicity, BA levels must be tightly regulated. An orphan nuclear receptor, Small Heterodimer Partner (SHP), plays a key role in this regulation, but how SHP senses the BA signal for feedback transcriptional responses is not clearly understood. We show an unexpected function of a nucleoporin,...

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Identifiers

PMID: 27412403
DOI: 10.1038/ncomms12179
PMCID: PMC4947186

Genes

SUMO2

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