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Article

Soluble FGFR4 extracellular domain inhibits FGF19-induced activation of FGFR4 signaling and prevents nonalcoholic fatty liver disease.

Biochemical and biophysical research communications - 17 Jun 2011

Chen Qiang, Jiang Yuan, An Yuan, Zhao Na, Zhao Yang, Yu Chundong

Abstract excerpt

Fibroblast growth factor receptor 4 (FGFR4) is a transmembrane tyrosine kinase receptor that plays a crucial role in the regulation of hepatic bile acid and lipid metabolism. FGFR4 underlies high-fat diet-induced hepatic steatosis, suggesting that inhibition of FGFR4 activation may be an effective way to prevent or treat nonalcoholic fatty liver disease (NAFLD). To determine whether neutralization of FGFR4...

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Source

Identifiers

PMID: 21616061
DOI: 10.1016/j.bbrc.2011.05.059

Genes

FGFR4
ECD
FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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