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Article

Molecular mechanisms of altered bile acid homeostasis in organic solute transporter-alpha knockout mice.

Digestive diseases (Basel, Switzerland) - 1 Jan 2011

Lan Tian, Haywood Jamie, Rao Anuradha, Dawson Paul A

Abstract excerpt

BACKGROUND/AIMS: Mutations in the apical sodium-dependent bile acid transporter (SLC10A2) block intestinal bile acid absorption, resulting in a compensatory increase in hepatic bile acid synthesis. Inactivation of the basolateral membrane bile acid transporter (OSTα-OSTβ) also impairs intestinal bile acid absorption, but hepatic bile acid synthesis was paradoxically repressed. We hypothesized that the altered...

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Identifiers

PMID: 21691100
DOI: 10.1159/000324124
PMCID: PMC3202926

Genes

FGFR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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